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A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.

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作者单位: Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. wan-lin.lo@path.utah.edu. [1] Division of Animal Physiology and Immunology, School of Life Sciences, Technical University of Munich, Freising, Germany. [2] Human Oncology and Pathogenesis Program, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [3] Department of Molecular Biology and Genetics, Izmir Institute of Technology, Gulbahce, Turkey. [4] Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. [5] Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. [6] Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. [7] Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California San Francisco, San Francisco, CA, USA. [8] Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.;Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.;Chan Zuckerberg Biohub, San Francisco, CA, USA.;Department of Medicine, University of California San Francisco, San Francisco, CA, USA.;Diabetes Center, University of California San Francisco, San Francisco, CA, USA.;Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, USA.;UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.;Parker Institute for Cancer Immunotherapy, University of California San Francisco, San Francisco, CA, USA.;Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA. [9] Division of Animal Physiology and Immunology, School of Life Sciences, Technical University of Munich, Freising, Germany. dietmar.zehn@tum.de. [10] Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California San Francisco, San Francisco, CA, USA. arthur.weiss@ucsf.edu. [11]
DOI 10.1038/s41590-023-01444-x
PMID 36914891
发布时间 2025-01-24
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