换一批
换一批Comprehensive molecular phenotyping of <i>ARID1A</i>-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
作者：
Chang,Xu [1]
;
Kie Kyon,Huang [2]
;
Jia Hao,Law [3]
;
Joy Shijia,Chua [4]
;
Taotao,Sheng [5]
;
Natasha M,Flores [6]
;
Melissa Pool,Pizzi [7]
;
Atsushi,Okabe [8]
;
Angie Lay Keng,Tan [2]
;
Feng,Zhu [4]
;
Vikrant,Kumar [2]
;
Xiaoyin,Lu [6]
;
Ana Morales,Benitez [6]
;
Benedict Shi Xiang,Lian [2]
;
Haoran,Ma [2]
;
Shamaine Wei Ting,Ho [5]
;
Kalpana,Ramnarayanan [2]
;
Chukwuemeka George,Anene-Nzelu [9]
;
Milad,Razavi-Mohseni [10]
;
Siti Aishah Binte,Abdul Ghani [11]
;
Su Ting,Tay [12]
;
Xuewen,Ong [13]
;
Ming Hui,Lee [2]
;
Yu Amanda,Guo [2]
;
Hassan,Ashktorab [2]
;
Duane,Smoot [2]
;
Shang,Li [14]
;
Anders Jacobsen,Skanderup [15]
;
Michael A,Beer [16]
;
Roger Sik Yin,Foo [2]
;
Joel Shi Hao,Wong [17]
;
Kaushal,Sanghvi [14]
;
Wei Peng,Yong [13]
;
Raghav,Sundar [9]
;
Atsushi,Kaneda [10]
;
Shyam,Prabhakar [18]
;
Pawel Karol,Mazur [18]
;
Jaffer A,Ajani [19]
;
Khay Guan,Yeoh [20]
;
Jimmy Bok-Yan,So [2]
;
Patrick,Tan [4]
;
Singapore Gastric Cancer Consortium [21]
作者单位：
Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.
[1]
Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.
[2]
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
[3]
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
[4]
Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.
[5]
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
[6]
Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
[7]
Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
[8]
Cardiovascular Research Institute, National University Health System, Singapore.
[9]
Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.
[10]
Montreal Heart Institute, Quebec, Québec, Canada.
[11]
Department of Medicine, University of Montreal, Quebec, Québec, Canada.
[12]
Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA.
[13]
Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.
[14]
Department of Medicine, Howard University, Washington, DC, USA.
[15]
Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA.
[16]
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
[17]
Department of General Surgery, Tan Tock Seng Hospital, Singapore.
[18]
Department of Haematology-Oncology, National University Health System, Singapore.
[19]
Cancer Science Institute of Singapore, National University of Singapore, Singapore.
[20]
Department of Haematology-Oncology, National University Cancer Institute, Singapore.
[21]
The N.1 Institute for Health, National University of Singapore, Singapore.
[22]
Singapore Gastric Cancer Consortium, Singapore.
[23]
Department of Gastroenterology and Hepatology, National University Health System, Singapore.
[24]
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.
[25]
Division of Surgical Oncology, National University Cancer Institute, Singapore.
[26]
SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.
[27]
Cellular and Molecular Research, National Cancer Centre, Singapore.
[28]
关键词
gastric cancer
主题词
人类(Humans);转录因子(Transcription Factors);胃肿瘤(Stomach Neoplasms);核蛋白质类(Nuclear Proteins);表观基因组学(Epigenomics);突变(Mutation);肿瘤微环境(Tumor Microenvironment);DNA结合蛋白质类(DNA-Binding Proteins);细胞周期蛋白质类(Cell Cycle Proteins)
DOI
10.1136/gutjnl-2022-328332
PMID
36918265
发布时间
2023-08-09
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Gut
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1651-1663页
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