换一批Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
第一作者：
William J,Young
第一单位：
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.;Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.
作者：
William J,Young [1]
;
Jeffrey,Haessler [2]
;
Jan-Walter,Benjamins [3]
;
Linda,Repetto [4]
;
Jie,Yao [5]
;
Aaron,Isaacs [6]
;
Andrew R,Harper [7]
;
Julia,Ramirez [8]
;
Sophie,Garnier [9]
;
Stefan,van Duijvenboden [10]
;
Antoine R,Baldassari [11]
;
Maria Pina,Concas [12]
;
ThuyVy,Duong [13]
;
Luisa,Foco [14]
;
Jonas L,Isaksen [15]
;
Hao,Mei [16]
;
Raymond,Noordam [17]
;
Casia,Nursyifa [18]
;
Anne,Richmond [19]
;
Meddly L,Santolalla [20]
;
Colleen M,Sitlani [21]
;
Negin,Soroush [22]
;
Sébastien,Thériault [23]
;
Stella,Trompet [24]
;
Stefanie,Aeschbacher [25]
;
Fariba,Ahmadizar [26]
;
Alvaro,Alonso [27]
;
Jennifer A,Brody [21]
;
Archie,Campbell [28]
;
Adolfo,Correa [29]
;
Dawood,Darbar [30]
;
Antonio,De Luca [31]
;
Jean-François,Deleuze [32]
;
Christina,Ellervik [33]
;
Christian,Fuchsberger [34]
;
Anuj,Goel [7]
;
Christopher,Grace [7]
;
Xiuqing,Guo [35]
;
Torben,Hansen [18]
;
Susan R,Heckbert [36]
;
Rebecca D,Jackson [37]
;
Jan A,Kors [38]
;
Maria Fernanda,Lima-Costa [39]
;
Allan,Linneberg [40]
;
Peter W,Macfarlane [41]
;
Alanna C,Morrison [42]
;
Pau,Navarro [19]
;
David J,Porteous [43]
;
Peter P,Pramstaller [44]
;
Alexander P,Reiner [45]
;
Lorenz,Risch [46]
;
Ulrich,Schotten [47]
;
Xia,Shen [48]
;
Gianfranco,Sinagra [31]
;
Elsayed Z,Soliman [49]
;
Monika,Stoll [50]
;
Eduardo,Tarazona-Santos [51]
;
Andrew,Tinker [52]
;
Katerina,Trajanoska [53]
;
Eric,Villard [9]
;
Helen R,Warren [52]
;
Eric A,Whitsel [54]
;
Kerri L,Wiggins [21]
;
Dan E,Arking [13]
;
Christy L,Avery [11]
;
David,Conen [55]
;
Giorgia,Girotto [56]
;
Niels,Grarup [18]
;
Caroline,Hayward [57]
;
J Wouter,Jukema [58]
;
Dennis O,Mook-Kanamori [59]
;
Morten Salling,Olesen [60]
;
Sandosh,Padmanabhan [61]
;
Bruce M,Psaty [62]
;
Cristian,Pattaro [14]
;
Antonio Luiz P,Ribeiro [63]
;
Jerome I,Rotter [64]
;
Bruno H,Stricker [22]
;
Pim,van der Harst [65]
;
Cornelia M,van Duijn [66]
;
Niek,Verweij [3]
;
James G,Wilson [67]
;
Michele,Orini [68]
;
Philippe,Charron [69]
;
Hugh,Watkins [7]
;
Charles,Kooperberg [2]
;
Henry J,Lin [35]
;
James F,Wilson [70]
;
Jørgen K,Kanters [15]
;
Nona,Sotoodehnia [71]
;
Borbala,Mifsud [72]
;
Pier D,Lambiase [68]
;
Larisa G,Tereshchenko [73]
;
Patricia B,Munroe [74]
作者单位：
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.;Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.
[1]
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
[2]
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
[3]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
[4]
Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
[5]
Dept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.;Maastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.
[6]
Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.;Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
[7]
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.;Institute of Cardiovascular Sciences, University of College London, London, UK.;Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain and Center of Biomedical Research Network, Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain.
[8]
Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.;ICAN Institute for Cardiometabolism and Nutrition, Paris, 75013, France.
[9]
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.;Institute of Cardiovascular Sciences, University of College London, London, UK.
[10]
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[11]
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
[12]
McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[13]
Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
[14]
Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
[15]
Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
[16]
Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
[17]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[18]
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
[19]
Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.;Emerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, 15152, Peru.
[20]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[21]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[22]
Population Health Research Institute, McMaster University, Hamilton, ON, Canada.;Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec, QC, Canada.
[23]
Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.;Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
[24]
Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
[25]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Julius Global Health, University Utrecht Medical Center, Utrecht, the Netherlands.
[26]
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
[27]
Usher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.;Health Data Research UK, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.;Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
[28]
Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
[29]
Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
[30]
Cardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.
[31]
Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.;Laboratory of Excellence GENMED (Medical Genomics), Paris, France.;Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France.
[32]
Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.;Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
[33]
Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.;Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.;Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
[34]
Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.;Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.;Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
[35]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.
[36]
Center for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA.
[37]
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands.
[38]
Instituto René Rachou, fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
[39]
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, København, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[40]
Institute of Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
[41]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[42]
Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.;Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
[43]
Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.;Department of Neurology, University of Lübeck, Lübeck, Germany.
[44]
Department of Epidemiology, University of Washington, Seattle, WA, USA.;Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
[45]
Labormedizinisches zentrum Dr. Risch, Vaduz, Liechtenstein.;Faculty of Medical Sciences, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein.;Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland.
[46]
Dept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
[47]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.;Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Nansha District, Guangzhou, China.
[48]
Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC, USA.
[49]
Maastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.;Dept. of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.;Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany.
[50]
Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
[51]
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.;NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
[52]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
[53]
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.
[54]
Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
[55]
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.;Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
[56]
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
[57]
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.;Netherlands Heart Institute, Utrecht, the Netherlands.;Durrer Center for Cardiovascular Research, Amsterdam, the Netherlands.
[58]
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, the Netherlands.;Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands, Leiden, the Netherlands.
[59]
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
[60]
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
[61]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Health Systems and Population Health, University of Washington, Seattte, WA, USA.
[62]
Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Minas Gerais, Brazil.;Cardiology Service and Telehealth Center, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Belo Horizonte, Minas Gerais, Brazil.
[63]
Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.;Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.;Departments of Pediatrics and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
[64]
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.;Department of Cardiology, Heart and Lung Division, University Medical Center Utrecht, Utrecht, the Netherlands.
[65]
Nuffield Department of Population Health, University of Oxford, Oxford, UK.;Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
[66]
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.;Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
[67]
Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.;Institute of Cardiovascular Sciences, University of College London, London, UK.
[68]
Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.;ICAN Institute for Cardiometabolism and Nutrition, Paris, 75013, France.;APHP, Cardiology Department, Pitié-Salpêtrière Hospital, Paris, 75013, France.;APHP, Département de Génétique, Centre de Référence Maladies Cardiaques Héréditaires, Pitié-Salpêtrière Hospital, Paris, 75013, France.
[69]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.;MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
[70]
Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
[71]
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.;Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
[72]
Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. tereshl@ccf.org.;Department of Medicine, Cardiovascular Division, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. tereshl@ccf.org.
[73]
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.;NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.
[74]
医学主题词
人类(Humans);心血管疾病(Cardiovascular Diseases);房室传导阻滞(Atrioventricular Block);全基因组关联研究(Genome-Wide Association Study);危险因素(Risk Factors);心律失常, 心性(Arrhythmias, Cardiac);心电描记术(Electrocardiography)
DOI
10.1038/s41467-023-36997-w
PMID
36918541
发布时间
2025-01-07
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