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Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b.

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第一作者： Layla,Hosseini-Gerami

第一单位： Centre for Molecular Informatics, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.;AbsoluteAi Ltd, London, UK.

作者： Layla,Hosseini-Gerami ^[1] ; Elena,Ficulle ^[2] ; Neil,Humphryes-Kirilov ^[3] ; David C,Airey ^[4] ; James,Scherschel ^[4] ; Sarubini,Kananathan ^[5] ; Brian J,Eastwood ^[6] ; Suchira,Bose ^[5] ; David A,Collier ^[7] ; Emma,Laing ^[8] ; David,Evans ^[9] ; Howard,Broughton ^[10] ; Andreas,Bender ^[11]

作者单位： Centre for Molecular Informatics, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.;AbsoluteAi Ltd, London, UK. ^[1] Eli Lilly and Company, Windlesham, UK.;Zifo RnD Solutions, London, UK. ^[2] Eli Lilly and Company, Windlesham, UK.;C4X Discovery, Manchester, UK. ^[3] Eli Lilly and Company, Corporate Centre, Indianapolis, IN, USA. ^[4] Eli Lilly and Company, Windlesham, UK.;Eli Lilly and Company, Bracknell, UK. ^[5] Eli Lilly and Company, Windlesham, UK.;Eli Lilly and Company, Bracknell, UK.;Eli Lilly and Company (Retired), Bracknell, UK. ^[6] Eli Lilly and Company, Windlesham, UK.;Eli Lilly and Company, Bracknell, UK.;Social, Genetic and Developmental Psychiatry Centre, IoPPN, Kings's College London and Genetic and Genomic Consulting Ltd, Farnham, UK. ^[7] Eli Lilly and Company, Windlesham, UK.;GSK, Stevenage, UK. ^[8] Eli Lilly and Company, Windlesham, UK.;DeepMind, London, UK. ^[9] Eli Lilly and Company, Centro de Inovación, Alcobendas, Spain. ^[10] Centre for Molecular Informatics, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. ab454@cam.ac.uk. ^[11]

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