The clinical application of polygenic risk scores: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).

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作者： Aya,Abu-El-Haija ^[1] ; Honey V,Reddi ^[2] ; Hannah,Wand ^[3] ; Nancy C,Rose ^[4] ; Mari,Mori ^[5] ; Emily,Qian ^[6] ; Michael F,Murray ^[7] ; ACMG Professional Practice and Guidelines Committee. Electronic address: documents@acmg.net ^[8]

作者单位： Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA; Harvard Medical School, Boston, MA. ^[1] Department of Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI. ^[2] Division of Cardiovascular Medicine, Department of Medicine, Stanford Medicine, Stanford, CA. ^[3] Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Utah Health, Salt Lake City, UT. ^[4] Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH; Genetic and Genomic Medicine, Nationwide Children's Hospital, Columbus, OH. ^[5] Department of Genetics, Yale University, New Haven, CT. ^[6] Yale School of Medicine, New Haven, CT. ^[7] American College of Medical Genetics and Genomics, Bethesda, MD. ^[8]

关键词 Clinical applications Limitations and challenges Polygenic risk scores

主题词人类(Humans);美国(United States);遗传学, 医学(Genetics, Medical);基因组学(Genomics);基因检测(Genetic Testing)

DOI 10.1016/j.gim.2023.100803

PMID 36920474

发布时间 2023-11-29

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