TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies.

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作者： Elizabeth,Carideo Cunniff ^[1] ; Yosuke,Sato ^[1] ; Doanh,Mai ^[1] ; Vicky A,Appleman ^[1] ; Shinji,Iwasaki ^[2] ; Vihren,Kolev ^[1] ; Atsushi,Matsuda ^[2] ; Judy,Shi ^[1] ; Michiyo,Mochizuki ^[2] ; Masato,Yoshikawa ^[2] ; Jian,Huang ^[1] ; Luhua,Shen ^[1] ; Satyajeet,Haridas ^[1] ; Vaishali,Shinde ^[1] ; Chris,Gemski ^[1] ; Emily R,Roberts ^[1] ; Omid,Ghasemi ^[1] ; Hojjat,Bazzazi ^[1] ; Saurabh,Menon ^[1] ; Tary,Traore ^[1] ; Pu,Shi ^[1] ; Tennille D,Thelen ^[1] ; Joseph,Conlon ^[1] ; Adnan O,Abu-Yousif ^[1] ; Christopher,Arendt ^[1] ; Michael H,Shaw ^[1] ; Masanori,Okaniwa ^[1]

作者单位： Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts. ^[1] Takeda Pharmaceutical Company, Ltd., Fujisawa, Kanagawa, Japan. ^[2]

主题词动物(Animals);人类(Humans);小鼠(Mice);细胞因子类(Cytokines);免疫, 先天(Immunity, Innate);干扰素类(Interferons);肿瘤(Neoplasms);信号传导(Signal Transduction);肿瘤微环境(Tumor Microenvironment);临床试验, Ⅰ期(主题)(Clinical Trials, Phase I as Topic)

DOI 10.1158/2767-9764.CRC-21-0161

PMID 36923556

发布时间 2023-07-31

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Cancer research communications

2022年2卷6期

489-502页

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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies.

Cancer research communications

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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies.

Cancer research communications

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Cancer research communications

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