首页> European journal of medicinal chemistry> Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.

Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.

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第一作者： Max,Van Hoof

第一单位： Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium.

作者： Max,Van Hoof ^[1] ; Sandra,Claes ^[2] ; Matic,Proj ^[3] ; Tom,Van Loy ^[2] ; Dominique,Schols ^[2] ; Stanislav,Gobec ^[3] ; Wim,Dehaen ^[1] ; Steven,De Jonghe ^[4]

作者单位： Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium. ^[1] KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000, Leuven, Belgium. ^[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia. ^[3] KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000, Leuven, Belgium. Electronic address: steven.dejonghe@kuleuven.be. ^[4]

关键词 1,2,3-triazolo[4,5-d]pyrimidine CCR7 antagonist CXCR2 antagonist Hit finding SAR optimization

医学主题词人类(Humans);受体, CCR7(Receptors, CCR7);构效关系(Structure-Activity Relationship);信号传导(Signal Transduction);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);嘧啶类(Pyrimidines)

DOI 10.1016/j.ejmech.2023.115240

PMID 36924670

发布时间 2023-04-04

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