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首页> American journal of human genetics> Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis.

Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis.

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作者： Nai-Ning,Wang ^[1] ; Yan,Zhang ^[1] ; Feng,Jiang ^[1] ; Dong-Li,Zhu ^[1] ; Chen-Xi,Di ^[1] ; Shou-Ye,Hu ^[2] ; Xiao-Feng,Chen ^[1] ; Li-Qiang,Zhi ^[2] ; Yu,Rong ^[1] ; Xin,Ke ^[1] ; Yuan-Yuan,Duan ^[1] ; Shan-Shan,Dong ^[1] ; Tie-Lin,Yang ^[1] ; Zhi,Yang ^[3] ; Yan,Guo ^[4]

作者单位： Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China. ^[1] Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, P.R. China. ^[2] Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address: xgcgfd@126.com. ^[3] Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address: guoyan253@xjtu.edu.cn. ^[4]

关键词 ACTR2 SNP SPRED2 enhancer rheumatoid arthritis signal amplifier synovial fibroblasts variant

主题词人类(Humans);关节炎, 类风湿(Arthritis, Rheumatoid);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);染色体(Chromosomes);成纤维细胞(Fibroblasts);基因表达调控(Gene Expression Regulation);全基因组关联研究(Genome-Wide Association Study);阻遏蛋白质类(Repressor Proteins);肌动蛋白相关蛋白质2(Actin-Related Protein 2)

DOI 10.1016/j.ajhg.2023.02.012

PMID 36924774

发布时间 2023-10-07

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American journal of human genetics

American journal of human genetics

2023年110卷4期

625-637页

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