首页> The Journal of clinical investigation> Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells.

Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells.

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第一作者： Xinyi,Jiang

第一单位： Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

作者： Xinyi,Jiang ^[1] ; Jian,Lin ^[2] ; Chengfang,Shangguan ^[3] ; Xiaoyao,Wang ^[1] ; Bin,Xiang ^[4] ; Juan,Chen ^[1] ; Hezhou,Guo ^[1] ; Wu,Zhang ^[1] ; Jun,Zhang ^[3] ; Yan,Shi ^[3] ; Jiang,Zhu ^[5] ; Hui,Yang ^[6]

作者单位： Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[1] Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.;Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China. ^[2] Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[3] Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. ^[4] Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.;Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[5] Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.;Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[6]

关键词 Colorectal cancer Immunology Immunotherapy Oncology T cells

医学主题词人类(Humans);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞系, 肿瘤(Cell Line, Tumor);结肠肿瘤(Colonic Neoplasms);免疫疗法(Immunotherapy);STAT5转录因子(STAT5 Transcription Factor);肿瘤微环境(Tumor Microenvironment)

DOI 10.1172/JCI160790

PMID 36927693

发布时间 2023-12-13

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