Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.

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第一作者： Parasvi S,Patel

第一单位： Princess Margaret Cancer Centre, University Health Network, Toronto, OntarioM5G 1L7, Canada.

作者： Parasvi S,Patel ^[1] ; Arash,Algouneh ^[2] ; Rehna,Krishnan ^[1] ; John J,Reynolds ^[3] ; Kevin C J,Nixon ^[1] ; Jun,Hao ^[4] ; Jihoon,Lee ^[1] ; Yue,Feng ^[1] ; Chehronai,Fozil ^[5] ; Mia,Stanic ^[1] ; Talya,Yerlici ^[2] ; Peiran,Su ^[1] ; Fraser,Soares ^[2] ; Elisabeth,Liedtke ^[3] ; Gil,Prive ^[1] ; Gary D,Baider ^[2] ; Miquel Angel,Pujana ^[1] ; Karim,Mekhail ^[1] ; Housheng Hansen,He ^[2] ; Anne,Hakem ^[1] ; Grant S,Stewart ^[6] ; Razqallah,Hakem ^[7]

作者单位： Princess Margaret Cancer Centre, University Health Network, Toronto, OntarioM5G 1L7, Canada. ^[1] Department of Medical Biophysics, University of Toronto, OntarioM5G 1L7, Canada. ^[2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, OntarioM5S 1A8, Canada. ^[3] Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. ^[4] Department of Cell and Systems Biology, University of Toronto, OntarioM5S 3G5, Canada. ^[5] Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, ON, Canada. ^[6] Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona 08908, Catalonia, Spain. ^[7]