Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.

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作者： Sean S,Keating ^[1] ; Adekunle T,Bademosi ^[1] ; Rebecca,San Gil ^[2] ; Adam K,Walker ^[3]

作者单位： Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia. ^[1] Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia. r.sangil@uq.edu.au. ^[2] Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia. adam.walker@uq.edu.au. ^[3]

关键词 Acetylated TDP-43 Endogenous gene tagging LLPS Motor neuron disease TDP-43 loss of function

主题词人类(Humans);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);细胞核(Cell Nucleus);细胞质(Cytoplasm);DNA结合蛋白质类(DNA-Binding Proteins);额颞叶痴呆(Frontotemporal Dementia)

DOI 10.1007/s00018-023-04739-2

PMID 36930291

发布时间 2023-04-18

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准确一般字义偏差语意偏离译文作用小提交