A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery.

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作者： Liang Meng,Wee ^[1] ; Alexander B,Tong ^[2] ; Alfredo Jose,Florez Ariza ^[3] ; Cristhian,Cañari-Chumpitaz ^[4] ; Patricia,Grob ^[5] ; Eva,Nogales ^[6] ; Carlos J,Bustamante ^[7]

作者单位： QB3-Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA. ^[1] QB3-Berkeley, Berkeley, CA, USA; Department of Chemistry, University of California Berkeley, Berkeley, CA, USA. ^[2] QB3-Berkeley, Berkeley, CA, USA; Biophysics Graduate Group, University of California Berkeley, Berkeley, CA, USA. ^[3] QB3-Berkeley, Berkeley, CA, USA; Department of Chemistry, University of California Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA. ^[4] QB3-Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA. ^[5] QB3-Berkeley, Berkeley, CA, USA; Biophysics Graduate Group, University of California Berkeley, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Electronic address: enogales@lbl.gov. ^[6] QB3-Berkeley, Berkeley, CA, USA; Biophysics Graduate Group, University of California Berkeley, Berkeley, CA, USA; Department of Chemistry, University of California Berkeley, Berkeley, CA, USA; Department of Physics, University of California Berkeley, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA; Kavli Energy Nanoscience Institute, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Electronic address: carlosb@berkeley.edu. ^[7]

关键词 RNA polymerase allostery coupling fidelity force ribosome transcription translation

主题词转录, 遗传(Transcription, Genetic);大肠杆菌(Escherichia coli);指导DNA的RNA聚合酶类(DNA-Directed RNA Polymerases);核糖体(Ribosomes);大肠杆菌蛋白质类(Escherichia coli Proteins)

DOI 10.1016/j.cell.2023.02.008

PMID 36931247

发布时间 2024-05-26

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