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Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia.

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第一作者： Jiali,Cheng

第一单位： Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Qiaokou District, 1095 Jiefang Avenue, Wuhan, China.

作者： Jiali,Cheng ^[1] ; Tong,Ge ^[1] ; Xiaojian,Zhu ^[1] ; Jue,Wang ^[1] ; Yuhao,Zeng ^[2] ; Wei,Mu ^[1] ; Haodong,Cai ^[1] ; Zhenyu,Dai ^[1] ; Jin,Jin ^[1] ; Yongkun,Yang ^[3] ; Guang,Hu ^[3] ; Xia,Mao ^[1] ; Jianfeng,Zhou ^[1] ; Li,Zhu ^[4] ; Liang,Huang ^[5]

作者单位： Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Qiaokou District, 1095 Jiefang Avenue, Wuhan, China. ^[1] Department of Internal Medicine, Cleveland Clinic, Akron General, Akron, OH, USA. ^[2] IASO Biotherapeutics, Nanjing, China. ^[3] Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Qiaokou District, 1095 Jiefang Avenue, Wuhan, China. judy831109@tjh.tjmu.edu.cn. ^[4] Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Qiaokou District, 1095 Jiefang Avenue, Wuhan, China. lhuang@tjh.tjmu.edu.cn. ^[5]

关键词 AML Antigen density CD70 Chidamide Decitabine Nanobody-CAR T-cells

医学主题词人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);氨基吡啶类(Aminopyridines);免疫疗法, 过继(Immunotherapy, Adoptive);T淋巴细胞(T-Lymphocytes)

DOI 10.1007/s00262-023-03422-6

PMID 36932256

发布时间 2024-12-31

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