Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish.

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第一作者： Lixuan,Bian

第一单位： Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.

作者： Lixuan,Bian ^[1] ; Vu Thanh,Nguyen ^[2] ; Junya,Tamaoki ^[1] ; Yuka,Endo ^[1] ; Guilin,Dong ^[1] ; Ayaka,Sato ^[1] ; Makoto,Kobayashi ^[3]

作者单位： Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. ^[1] Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan; Division of Aquaculture Biotechnology, Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Viet Nam. ^[2] Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. Electronic address: makobayash@md.tsukuba.ac.jp. ^[3]

关键词 Eating defects Keap1–Nrf2 pathway Nrf2-inhibiting compounds Visual cycle genes keap1a;keap1b-double knockout zebrafish

主题词动物(Animals);动物, 基因修饰(Animals, Genetically Modified);载体蛋白质类(Carrier Proteins);基因敲除技术(Gene Knockout Techniques);幼虫(Larva);哺乳动物(Mammals);NF-E2相关因子2(NF-E2-Related Factor 2);氧化性应激(Oxidative Stress);斑马鱼(Zebrafish);斑马鱼蛋白质类(Zebrafish Proteins)

DOI 10.1016/j.redox.2023.102673

PMID 36934645

发布时间 2023-06-10

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Redox biology

2023年62卷

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Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish.

Redox biology

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Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish.

Redox biology

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Redox biology

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