Prediction and validation of monoclonal antibodies separation in aqueous two-phase system using molecular dynamic simulation.

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第一作者： Yibo,Guo

第一单位： State Key Laboratory of Bioreactor Engineering, Department of Bioengineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China.

作者： Yibo,Guo ^[1] ; Xi,Chen ^[1] ; Xue,Yu ^[2] ; Junfen,Wan ^[3] ; Xuejun,Cao ^[4]

作者单位： State Key Laboratory of Bioreactor Engineering, Department of Bioengineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China. ^[1] Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, 253023, P.R. China. ^[2] State Key Laboratory of Bioreactor Engineering, Department of Bioengineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China. Electronic address: wanjunfen@ecust.edu.cn. ^[3] State Key Laboratory of Bioreactor Engineering, Department of Bioengineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China. Electronic address: caoxj@ecust.edu.cn. ^[4]

关键词 Aqueous two-phase system Molecular dynamic simulation Monoclonal antibodies Prediction model

主题词抗体, 单克隆(Antibodies, Monoclonal);分子动力学模拟(Molecular Dynamics Simulation);水(Water);环氧乙烷(Ethylene Oxide)

DOI 10.1016/j.chroma.2023.463921

PMID 36940643

发布时间 2023-03-31

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