首页> Cell reports> Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines.

Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines.

导出 OA

翻译打印收藏纠错

第一作者： Thayne H,Dickey

第一单位： Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20894, USA.

作者： Thayne H,Dickey ^[1] ; Rui,Ma ^[1] ; Sachy,Orr-Gonzalez ^[1] ; Tarik,Ouahes ^[1] ; Palak,Patel ^[1] ; Holly,McAleese ^[1] ; Brandi,Butler ^[1] ; Elizabeth,Eudy ^[2] ; Brett,Eaton ^[2] ; Michael,Murphy ^[2] ; Jennifer L,Kwan ^[3] ; Nichole D,Salinas ^[1] ; Michael R,Holbrook ^[2] ; Lynn E,Lambert ^[1] ; Niraj H,Tolia ^[4]

作者单位： Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20894, USA. ^[1] Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Frederick, MD 21702, USA. ^[2] Epidemiology and Population Studies Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20894, USA. ^[3] Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20894, USA. Electronic address: niraj.tolia@nih.gov. ^[4]

关键词 CP: Immunology CP: Microbiology SPEEDesign glycosylation immunogen nanoparticle stabilized structural vaccinology structure-based design

医学主题词动物(Animals);小鼠(Mice);抗体, 病毒(Antibodies, Viral);抗体, 中和(Antibodies, Neutralizing);纳米粒子(Nanoparticles)

DOI 10.1016/j.celrep.2023.112266

PMID 36943870

发布时间 2024-10-05

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交