首页> Arthritis research & therapy> TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo.

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo.

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第一作者： Kun,Wang

第一单位： Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, China.;Department of Orthopedics, Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, 3025 Shennan Middle Road, Shenzhen, 518033, China.

作者： Kun,Wang ^[1] ; Dengbo,Yao ^[1] ; Yuxi,Li ^[2] ; Ming,Li ^[2] ; Weike,Zeng ^[3] ; Zhuangyao,Liao ^[2] ; Engming,Chen ^[2] ; Shixin,Lu ^[2] ; Kaihui,Su ^[2] ; Zhen,Che ^[2] ; Yuwei,Liang ^[2] ; Peng,Wang ^[4] ; Lin,Huang ^[5]

作者单位： Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, China.;Department of Orthopedics, Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, 3025 Shennan Middle Road, Shenzhen, 518033, China. ^[1] Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. ^[2] Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. ^[3] Department of Orthopedics, Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, 3025 Shennan Middle Road, Shenzhen, 518033, China. wangp57@mail.sysu.edu.cn. ^[4] Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. huangl5@mail.sysu.edu.cn.;Department of Orthopedics, Nangchang First Hospital, Nanchang, China. huangl5@mail.sysu.edu.cn. ^[5]

关键词 Apoptosis IDD Inflammation Intervertebral disc degeneration TAK-715 p38MAPK