Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy.

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作者： Yoshihito,Nihei ^[1] ; Kei,Haniuda ^[2] ; Mizuki,Higashiyama ^[2] ; Shohei,Asami ^[2] ; Hiroyuki,Iwasaki ^[2] ; Yusuke,Fukao ^[1] ; Maiko,Nakayama ^[2] ; Hitoshi,Suzuki ^[1] ; Mika,Kikkawa ^[1] ; Saiko,Kazuno ^[1] ; Yoshiki,Miura ^[3] ; Yusuke,Suzuki ^[3] ; Daisuke,Kitamura ^[3]

作者单位： Department of Nephrology, Juntendo University Faculty of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. ^[1] Division of Cancer Cell Biology, Research Institute for Biomedical Sciences, Tokyo University of Science, Tokyo 278-0022, Japan. ^[2] Laboratory of Proteomics and Biomolecular Science, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. ^[3]

主题词小鼠(Mice);动物(Animals);肾小球肾炎, IGA(Glomerulonephritis, IGA);肾小球系膜细胞(Mesangial Cells);膜收缩蛋白(Spectrin);免疫球蛋白A(Immunoglobulin A);自身抗体(Autoantibodies)

DOI 10.1126/sciadv.add6734

PMID 36947618

发布时间 2023-04-07

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Science advances

2023年9卷12期

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Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy.

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Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy.

Science advances

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Science advances

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