Cardiomyocyte hyperplasia and immaturity but not hypertrophy are characteristic features of patients with RASopathies.

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作者： Jörg-Detlef,Drenckhahn ^[1] ; Luka,Nicin ^[2] ; Sara,Akhouaji ^[1] ; Svenja,Krück ^[1] ; Anna Eva,Blank ^[1] ; Anne,Schänzer ^[3] ; Uygar,Yörüker ^[4] ; Christian,Jux ^[1] ; Lukas,Tombor ^[5] ; Wesley,Abplanalp ^[5] ; David,John ^[5] ; Andreas M,Zeiher ^[5] ; Stefanie,Dimmeler ^[5] ; Stefan,Rupp ^[6]

作者单位： Department of Pediatric Cardiology, Intensive Care Medicine and Congenital Heart Disease, Justus Liebig University Giessen, Giessen, Germany. ^[1] Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany. ^[2] Institute of Neuropathology, Justus Liebig University Giessen, Giessen, Germany. ^[3] Department of Pediatric Cardiac Surgery, University Hospital Giessen, Justus Liebig University Giessen, Giessen, Germany. ^[4] Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany; Cardiopulmonary Institute, Goethe University Frankfurt, Frankfurt, Germany; German Center for Cardiovascular Research, RheinMain, Frankfurt, Germany. ^[5] Department of Pediatric Cardiology, Intensive Care Medicine and Congenital Heart Disease, Justus Liebig University Giessen, Giessen, Germany. Electronic address: stefan.rupp@paediat.med.uni-giessen.de. ^[6]

关键词 Cardiac hyperplasia Cardiomyocyte proliferation Hypertrophic cardiomyopathy Noonan syndrome RASopathy