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Transcriptomic landscapes of effective and failed liver regeneration in humans.

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第一作者： Patrick,Starlinger

第一单位： Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, Rochester, MN, USA.;Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

作者： Patrick,Starlinger ^[1] ; Laura,Brunnthaler ^[2] ; Chantal,McCabe ^[3] ; David,Pereyra ^[4] ; Jonas,Santol ^[5] ; Jessica,Steadman ^[6] ; Matthias,Hackl ^[7] ; Susanna,Skalicky ^[7] ; Hubert,Hackl ^[8] ; Raphael,Gronauer ^[8] ; Daniel,O'Brien ^[3] ; Renate,Kain ^[9] ; Petra,Hirsova ^[10] ; Gregory J,Gores ^[10] ; Chen,Wang ^[3] ; Thomas,Gruenberger ^[5] ; Rory L,Smoot ^[11] ; Alice,Assinger ^[2]

作者单位： Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, Rochester, MN, USA.;Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. ^[1] Center of Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria. ^[2] Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. ^[3] Department of Surgery, Medical University of Vienna, General Hospital, Vienna, Austria. ^[4] Department of Surgery, HPB Center, Viennese Health Network, Clinic Favoriten and Sigmund Freud Private University, Vienna, Austria. ^[5] Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, Rochester, MN, USA. ^[6] TAmiRNA GmbH, Vienna, Austria. ^[7] Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria. ^[8] Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria. ^[9] Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. ^[10] Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Mayo Clinic, Rochester, MN, USA.;Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. ^[11]

关键词 ALT, alanine aminotransferase AST, aspartate aminotransferase CASH, chemotherapy associated steatohepatitis DLR, dysfunctional LR DUSP-4 DUSP4, dual-specificity phosphatase 4 FDR, false discovery rate FLR, functional LR FPKM, fragments per kilobase of transcript per million mapped reads Human ICAM-1, intracellular adhesion molecule-1 IPA, Ingenuity Pathway Analysis IVCL, inferior vena cava ligation Inflammation LPS, lipopolysaccharide LR, liver regeneration LSEC, liver sinusoidal endothelial cell Liver regeneration MFI, mean fluorescence intensity MPO, myeloperoxidase NASH, non-alcoholic steatohepatitis Neutrophils PCA, principal component analysis POD1, 1 day after liver resection POD5, 5 days after liver resection STRING, Search Tool for the Retrieval of Interacting Genes/Proteins TMM, trimmed mean of M values TNF, tumour necrosis factor logCPM, log counts per million pTPM, protein-coding transcripts per million

DOI 10.1016/j.jhepr.2023.100683

PMID 36950091

发布时间 2025-05-30

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