Nonsteroidal anti-inflammatory drug diclofenac accelerates the emergence of antibiotic resistance via mutagenesis.

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作者： Xiangju,Li ^[1] ; Xue,Xue ^[1] ; Jia,Jia ^[2] ; Xiaocui,Zou ^[1] ; Yongjing,Guan ^[3] ; Long,Zhu ^[4] ; Zaizhao,Wang ^[5]

作者单位： Department of Aquaculture, College of Animal Science and Technology, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi, 712100, China. ^[1] State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. ^[2] College of Marine Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. ^[3] College of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang, Jiangsu, 222005, China. ^[4] Department of Aquaculture, College of Animal Science and Technology, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi, 712100, China. Electronic address: zzwang@nwsuaf.edu.cn. ^[5]

关键词 Antibiotic resistance bacteria Diclofenac Ecological risks Mutagenesis Nonsteroidal anti-inflammatory drug

主题词二氯酚酸(Diclofenac);大肠杆菌(Escherichia coli);血管紧张素受体拮抗剂(Angiotensin Receptor Antagonists);血管紧张素转换酶抑制药(Angiotensin-Converting Enzyme Inhibitors);诱变(Mutagenesis);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);抗药性, 微生物(Drug Resistance, Microbial)

DOI 10.1016/j.envpol.2023.121457

PMID 36958653

发布时间 2023-04-18

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