首页> Cell reports> Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.

Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.

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第一作者： Heng,Lyu

第一单位： Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China.

作者： Heng,Lyu ^[1] ; Le,Sun ^[1] ; Zhenyu,Guan ^[1] ; Jinxin,Li ^[2] ; Changsong,Yin ^[2] ; Yaoyang,Zhang ^[1] ; Hong,Jiang ^[3]

作者单位： Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China. ^[1] Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China. ^[2] Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: hongjiang@sioc.ac.cn. ^[3]

关键词 CP: Immunology CP: Molecular biology DNA binding OTUD3 TurboID cGAS cytosolic DNA complex deubiquitinase innate immune response proximity labeling ubiquitination

医学主题词核苷酸基转移酶类(Nucleotidyltransferases);免疫, 先天(Immunity, Innate);DNA(DNA);胞质溶胶(Cytosol)

DOI 10.1016/j.celrep.2023.112309

PMID 36966392

发布时间 2023-10-05

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