DHMMF, a natural flavonoid from Resina Draconis, inhibits hepatocellular carcinoma progression via inducing apoptosis and G2/M phase arrest mediated by DNA damage-driven upregulation of p21.

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作者： Yingying,Tian ^[1] ; Longyan,Wang ^[1] ; Xiaonan,Chen ^[1] ; Yanan,Zhao ^[1] ; Ailin,Yang ^[1] ; Huiming,Huang ^[1] ; Lishan,Ouyang ^[1] ; Daoran,Pang ^[2] ; Jinxin,Xie ^[1] ; Dongxiao,Liu ^[1] ; Pengfei,Tu ^[3] ; Jun,Li ^[4] ; Zhongdong,Hu ^[5]

作者单位： Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. ^[1] Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; Innovation Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. ^[2] Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: pengfeitu@163.com. ^[3] Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: drlj666@163.com. ^[4] Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: zdhu@bucm.edu.cn. ^[5]

关键词 Apoptosis DHMMF DNA damage G2/M arrest Hepatocellular carcinoma P21