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Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing.

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第一作者： Yang,Liu

第一单位： The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden.

作者： Yang,Liu ^[1] ; Manoj,Puthia ^[2] ; Eamon J,Sheehy ^[3] ; Ines,Ambite ^[4] ; Jitka,Petrlova ^[2] ; Sujeethkumar,Prithviraj ^[5] ; Maria Wimer,Oxborg ^[1] ; Sujeesh,Sebastian ^[1] ; Corina,Vater ^[6] ; Stefan,Zwingenberger ^[6] ; André,Struglics ^[1] ; Paul E,Bourgine ^[5] ; Fergal J,O'Brien ^[3] ; Deepak Bushan,Raina ^[7]

作者单位： The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden. ^[1] The Faculty of Medicine, Division of Dermatology and Venerology, Lund University, Lund 221 84, Sweden. ^[2] Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, 123 St. Stephens Green, Dublin, Ireland; Advanced Materials & Bioengineering Research (AMBER) Centre, RCSI, 123 St. Stephen's Green, Dublin 2, Ireland; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. ^[3] The Faculty of Medicine, Department of Laboratory Medicine, Division of Microbiology, Immunology and Glycobiology, Lund University, Lund 221 84, Sweden. ^[4] Department of Clinical Sciences Lund, Stem Cell Centre, Cell, Tissue & Organ Engineering Laboratory, Lund University, BMC B11, Lund 221 84, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden. ^[5] Trauma and Plastic Surgery, University Hospital Carl Gustav Carus at Technische Universität Dresden, University Center of Orthopedics, Dresden 01307, Germany. ^[6] The Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund University, BMC C12, Klinikgatan 28, Lund 221 84, Sweden. Electronic address: deepak.raina@med.lu.se. ^[7]

关键词 Bone morphogenetic protein Collagen-hydroxyapatite Controlled delivery Fracture healing Heterodimer