首页> Journal of medicinal chemistry> Structure-Activity Relationships of Truncated 1'-Homologated Carbaadenosine Derivatives as New PPARγ/δ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs.

Structure-Activity Relationships of Truncated 1'-Homologated Carbaadenosine Derivatives as New PPARγ/δ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs.

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第一作者： Young Eum,Hyun

第一单位： Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.

作者： Young Eum,Hyun ^[1] ; Seungchan,An ^[2] ; Minjae,Kim ^[1] ; In Guk,Park ^[2] ; Sanghee,Yoon ^[3] ; Hafiz Muhammad Ahmad,Javaid ^[4] ; Thi Ngoc Lan,Vu ^[3] ; Gyudong,Kim ^[5] ; Hongseok,Choi ^[1] ; Hyuk Woo,Lee ^[6] ; Minsoo,Noh ^[2] ; Joo Young,Huh ^[4] ; Sun,Choi ^[3] ; Hong-Rae,Kim ^[7] ; Lak Shin,Jeong ^[8]

作者单位： Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. ^[1] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.;Natural Products Research Institute, Seoul National University, Seoul 08826, Korea. ^[2] Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea. ^[3] College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Korea. ^[4] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.;College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Korea. ^[5] Future Medicine Co., Ltd., Seongnam 13449, Gyeonggi-do, Korea. ^[6] Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02708, Korea. ^[7] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.;Future Medicine Co., Ltd., Seongnam 13449, Gyeonggi-do, Korea. ^[8]

医学主题词 PPARγ(PPAR gamma);PPARδ(PPAR delta);脂联素(Adiponectin);PPARα(PPAR alpha);构效关系(Structure-Activity Relationship);配体(Ligands)

DOI 10.1021/acs.jmedchem.2c02071

PMID 36967575

发布时间 2023-06-07

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