Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.

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第一作者： Alba Clara,Fernández-Rilo

第一单位： Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, NA, Italy.

作者： Alba Clara,Fernández-Rilo ^[1] ; Nicola,Forte ^[2] ; Letizia,Palomba ^[3] ; Lea,Tunisi ^[1] ; Fabiana,Piscitelli ^[1] ; Roberta,Imperatore ^[4] ; Alfonso,Di Costanzo ^[5] ; Vincenzo,Di Marzo ^[6] ; Luigia,Cristino ^[7]

作者单位： Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, NA, Italy. ^[1] Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, NA, Italy; Heart and Lung Research Institute and Institute for Nutrition and Functional Foods with Centre NUTRISS, Université Laval, Quebec City, Canada. ^[2] University of Urbino "Carlo Bo", Urbino, Italy. ^[3] University of Sannio, Benevento, Italy. ^[4] Centre for Research and Training in Medicine of Aging, Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy. ^[5] Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, NA, Italy; Heart and Lung Research Institute and Institute for Nutrition and Functional Foods with Centre NUTRISS, Université Laval, Quebec City, Canada. Electronic address: vincenzo.di-marzo.1@ulaval.ca. ^[6] Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, NA, Italy. Electronic address: luigia.cristino@icb.cnr.it. ^[7]

关键词 2-AG 2-Arachidonoyl-glycerol Hypothalamus Obesity Orexin/hypocretin α-MSH

主题词小鼠(Mice);人类(Humans);动物(Animals);瘦素(Leptin);内源性大麻酚类(Endocannabinoids);α促黑素(alpha-MSH);前阿片黑素细胞皮质激素(Pro-Opiomelanocortin);下丘脑(Hypothalamus);肥胖症(Obesity);溶血磷脂素类(Lysophospholipids);小鼠, 近交系(Mice, Inbred Strains)

DOI 10.1016/j.molmet.2023.101713

PMID 36977433

发布时间 2023-05-12

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Molecular metabolism

2023年72卷

101713页

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Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.

Molecular metabolism

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Molecular metabolism

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Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.

Molecular metabolism

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Molecular metabolism

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