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Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.

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作者单位: Disease Intervention Technology Lab (DITL), Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore, Singapore. [1] Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. [2] Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [3] Singapore Institute of Technology, Singapore, Singapore. [4] Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [5] Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [6] SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [7] Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. [8] Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore. [9] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [10] Department of Pathology, National University Health System, Singapore, Singapore. [11] University Surgical Cluster, National University Health System, Singapore, Singapore. [12] School of Biological Science, Nanyang Technological University, Singapore, Singapore. [13] Department of Biological Science, National University of Singapore, Singapore, Singapore. [14] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [15] NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [16] Disease Intervention Technology Lab (DITL), Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore, Singapore. arv22@nus.edu.sg. [17] Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. arv22@nus.edu.sg. [18] NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. arv22@nus.edu.sg. [19]
DOI 10.1038/s41467-023-37223-3
PMID 36977662
发布时间 2023-04-19
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