Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators.

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作者： Huiqing,Chen ^[1] ; Zekun,Liu ^[1] ; Lixin,Gao ^[2] ; Li-Fang,Yu ^[3] ; Yubo,Zhou ^[1] ; Jie,Tang ^[2] ; Jia,Li ^[4] ; Fan,Yang ^[1]

作者单位： Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China. ^[1] National Center for Drug Screening, Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[2] School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. ^[3] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[4] Shanghai Greenchem & Biotech Co., Ltd., Shanghai 200062, China. ^[5]

关键词 3-amino-4,4-dimethyl lithocholic acid derivatives SHP1 anti-tumor selective activators structure–activity relationships

主题词蛋白酪氨酸磷酸酶, 非受体6型(Protein Tyrosine Phosphatase, Non-Receptor Type 6);信号传导(Signal Transduction);蛋白质酪氨酸磷酸酶类(Protein Tyrosine Phosphatases);磷酰化(Phosphorylation)

DOI 10.3390/molecules28062488

PMID 36985458

发布时间 2023-03-31

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准确一般字义偏差语意偏离译文作用小提交