首页> European journal of medicinal chemistry> An overview of compound properties, multiparameter optimization, and computational drug design methods for PARP-1 inhibitor drugs.

An overview of compound properties, multiparameter optimization, and computational drug design methods for PARP-1 inhibitor drugs.

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第一作者： Bhakti Umesh,Hirlekar

第一单位： Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, (NIPER Guwahati), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India, Sila Katamur (Halugurisuk), P.O.: Changsari, Dist: Kamrup, 781101, Guwahati, Assam, India.

作者： Bhakti Umesh,Hirlekar ^[1] ; Anila,Nuthi ^[1] ; Krishan Dev,Singh ^[1] ; Upadhyayula Suryanarayana,Murty ^[1] ; Vaibhav A,Dixit ^[2]

作者单位： Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, (NIPER Guwahati), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India, Sila Katamur (Halugurisuk), P.O.: Changsari, Dist: Kamrup, 781101, Guwahati, Assam, India. ^[1] Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, (NIPER Guwahati), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India, Sila Katamur (Halugurisuk), P.O.: Changsari, Dist: Kamrup, 781101, Guwahati, Assam, India. Electronic address: vaibhavadixit@gmail.com. ^[2]

关键词 Compound properties Computational drug design Match molecular pair analysis (MMPA)Multiparameter optimization MPO PARP-1 inhibitors SAR study

医学主题词药物设计(Drug Design);抗肿瘤药(Antineoplastic Agents)

DOI 10.1016/j.ejmech.2023.115300

PMID 36989813

发布时间 2023-04-14

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