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Structural elements promote architectural stripe formation and facilitate ultra-long-range gene regulation at a human disease locus.

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第一作者： Liang-Fu,Chen

第一单位： Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

作者： Liang-Fu,Chen ^[1] ; Hannah Katherine,Long ^[1] ; Minhee,Park ^[2] ; Tomek,Swigut ^[1] ; Alistair Nicol,Boettiger ^[3] ; Joanna,Wysocka ^[4]

作者单位： Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[1] Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[2] Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: boettiger@stanford.edu. ^[3] Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: wysocka@stanford.edu. ^[4]

关键词 3D genome architecture CTCF enhancer gene regulation loop extrusion stripe-associated structural element