Cerebral iron deficiency may induce depression through downregulation of the hippocampal glucocorticoid-glucocorticoid receptor signaling pathway.

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作者： Hong,Zhang ^[1] ; Lian,He ^[2] ; Songfei,Li ^[3] ; Manhuayun,Zhai ^[3] ; Siman,Ma ^[3] ; Ge,Jin ^[4] ; Minyan,Li ^[5] ; Fan,Zhou ^[5] ; Hua,Tian ^[5] ; Tuohutanguli,Nuerkaman ^[1] ; Qiruo,Sun ^[3] ; Yu,Zhang ^[3] ; Jincai,Hou ^[6] ; Guoxiang,Sun ^[7] ; Shiliang,Yin ^[8]

作者单位： School of Life science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. ^[1] Department of Pathology, Cancer Hospital of China Medical University, Shenyang 110042, China. ^[2] School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. ^[3] School of Pharmacy, Shenyang Medical College, Shenyang 110034, China. ^[4] Department of Hematology, General Hospital of Northern Theater Command, Shenyang 11016, China. ^[5] Pharmaceutical Research Institute, Shineway Pharmaceutical Co., Ltd, Beijing 100000, China. ^[6] School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: gxswmwys@163.com. ^[7] School of Pharmacy, Shenyang Medical College, Shenyang 110034, China. Electronic address: yslal@163.com. ^[8]

关键词 Cerebral iron deficiency Depression GC-GR signaling pathway Glucocorticoid receptor dysfunction Hypothalamic-pituitary-adrenal axis overreaction