Chemical probes for investigating protein liquid-liquid phase separation and aggregation.

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第一作者： Rui,Sun

第一单位： CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.

作者： Rui,Sun ^[1] ; Shenqing,Zhang ^[2] ; Yu,Liu ^[3] ; Dan,Li ^[4]

作者单位： CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China. ^[1] Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China. ^[2] CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China. Electronic address: liuyu@dicp.ac.cn. ^[3] Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China; WLA Laboratories, World Laureates Association, Shanghai 201203, China. Electronic address: lidan2017@sjtu.edu.cn. ^[4]

关键词 Amyloid aggregation Chemical probes Fluorescence imaging Neurodegenerative diseases PET tracer Protein condensation Protein liquid-liquid phase separation (LLPS)

主题词人类(Humans);体层摄影术, X线计算机(Tomography, X-Ray Computed);神经变性疾病(Neurodegenerative Diseases);淀粉样蛋白(Amyloid)

DOI 10.1016/j.cbpa.2023.102291

PMID 37004350

发布时间 2023-06-02

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