5-Alkoxy-1-aryl-3-polyfluoroalkylpyrazoles with Antinociceptive Activity: Partial Agonists of TRPV1 Ion Channels.

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作者： Olga G,Khudina ^[1] ; Yanina V,Burgart ^[1] ; Natalia A,Malkova ^[1] ; Evgeny V,Shchegolkov ^[1] ; Olga P,Krasnykh ^[2] ; Galina A,Triandafilova ^[2] ; Ksenia O,Malysheva ^[2] ; Sergey Yu,Solodnikov ^[2] ; Elisaveta S,Dubodel ^[3] ; Yuliya V,Korolkova ^[3] ; Sergey A,Kozlov ^[3] ; Sophia S,Borisevich ^[4] ; Evgenii S,Mozhaitsev ^[5] ; Victor I,Saloutin ^[1]

作者单位： Ural Branch of the Russian Academy of Sciences, Postovsky Institute of Organic Synthesis, S. Kovalevskoi St., 22, Ekaterinburg, 620108, Russia. ^[1] Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm, 614990, Russia. ^[2] The Russian Academy of Sciences, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya St., 16/10, Moscow, 117997, Russia. ^[3] The Russian Academy of Sciences, Ufa Institute of Chemistry, Octyabrya Av., 71, Ufa, 450078, Russia. ^[4] Siberian Branch of the Russian Academy of Sciences, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev Av., 9, Novosibirsk, 630090, Russia. ^[5]

关键词 5-alkoxypyrazoles alkylation analgesia molecular docking partial agonists the transient receptor potential vanilloid 1 (TRPV1)