首页> mBio> Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis.

Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis.

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第一作者： Arijit,Chakraborty

第一单位： Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.;Shriners Hospitals for Children Boston, Boston, Massachusetts, USA.

作者： Arijit,Chakraborty ^[1] ; Asel,Kabashi ^[2] ; Samuel,Wilk ^[2] ; Laurence G,Rahme ^[3]

作者单位： Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.;Shriners Hospitals for Children Boston, Boston, Massachusetts, USA. ^[1] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. ^[2] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.;Shriners Hospitals for Children Boston, Boston, Massachusetts, USA.;Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA. ^[3]

关键词 2-aminoacetophenone MvfR PqsR Pseudomonas aeruginosa Scd1 autophagy epigenetic reprogramming fatty acids histone deacetylation immunometabolism macrophages persistence quorum sensing

主题词铜绿假单胞菌(Pseudomonas aeruginosa);组蛋白脱乙酰基酶1(Histone Deacetylase 1);后成说, 遗传(Epigenesis, Genetic);脂肪酸类, 单不饱和(Fatty Acids, Monounsaturated);巨噬细胞(Macrophages);自噬(Autophagy)

DOI 10.1128/mbio.00159-23

PMID 37010415

发布时间 2025-03-31

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