Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity.

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第一作者： Zhikun,Yang

第一单位： College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology, Hangzhou 310014, China.

作者： Zhikun,Yang ^[1] ; Yue,Cai ^[1] ; Xue,Yang ^[2] ; Yasheng,Li ^[3] ; Qihao,Wu ^[4] ; Yanlei,Yu ^[1] ; Zhen,Chen ^[1] ; Bin,Wei ^[1] ; Jin-Miao,Tian ^[1] ; Xiaoze,Bao ^[1] ; Xinyi,Ye ^[1] ; Jianwei,Chen ^[1] ; Huawei,Zhang ^[1] ; Xiaozhou,Mou ^[2] ; Xuanrong,Sun ^[1] ; Hong,Wang ^[1]

作者单位： College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology, Hangzhou 310014, China. ^[1] General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China. ^[2] Department of Infectious Diseases & Anhui Center for Surveillance of Bacterial Resistance, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. ^[3] Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.;Institute of Biomolecular Design & Discovery, Yale University, West Haven, Connecticut 06516, United States. ^[4]

主题词人类(Humans);抗药性, 肿瘤(Drug Resistance, Neoplasm);抗药性, 多药(Drug Resistance, Multiple);多柔比星(Doxorubicin)

DOI 10.1021/acs.jmedchem.2c01999

PMID 37011035

发布时间 2023-06-07

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