Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification.

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第一作者： Xiao-Yu,Wang

第一单位： State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, China.;Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China.

作者： Xiao-Yu,Wang ^[1] ; Chun-Jing,Chen ^[2] ; Yao-Hui,He ^[2] ; Lian-Shuai,Ding ^[2] ; Yi-Fan,Wu ^[2] ; Cheng-Ting,Huang ^[2] ; Jun,Wu ^[3] ; Rong,Ding ^[2] ; Yu-Hua,Xue ^[2] ; Zhi-Wei,Lin ^[4] ; Peng-Xiang,Xu ^[4] ; Yi-Le,Wu ^[5] ; Wen,Liu ^[2] ; Ji-Jun,Li ^[6] ; Si-Ming,Chen ^[2] ; Yu-Fen,Zhao ^[7] ; Ji-Yang,Dong ^[8] ; Qiang,Zhou ^[9] ; Xiang,Gao ^[2]

作者单位： State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, China.;Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China. ^[1] State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, China. ^[2] State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, China.;Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA. ^[3] Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China. ^[4] Institute of Drug Discovery Technology, Ningbo University, Ningbo, Zhejiang, 315221, China. ^[5] Research Center for Precision Diagnostic Omics Technology, Phobiology Technology Co., Ltd., Shenzhen, Guangdong, 518000, China. ^[6] Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China.;Institute of Drug Discovery Technology, Ningbo University, Ningbo, Zhejiang, 315221, China. ^[7] Department of Electronic Science, Xiamen University, Xiamen, Fujian, 361102, China. ^[8] Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA. ^[9]

关键词 CDK9 Isobaric Labeling Phosphorus Reagents Protein Quantification iSIPL

主题词蛋白质组(Proteome);串联质谱法(Tandem Mass Spectrometry);磷酰化(Phosphorylation);肽类(Peptides);同位素标记(Isotope Labeling);同位素(Isotopes)

DOI 10.1002/anie.202303656

PMID 37016511

发布时间 2023-05-19

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