首页> Alzheimer's & dementia : the journal of the Alzheimer's Association> Effects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer's disease.

Effects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer's disease.

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第一作者： Amanda Hazel,Dilmore

第一单位： Department of Pediatrics, University of California San Diego, La Jolla, California, USA.;Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA.

作者： Amanda Hazel,Dilmore ^[1] ; Cameron,Martino ^[2] ; Bryan J,Neth ^[3] ; Kiana A,West ^[4] ; Jasmine,Zemlin ^[5] ; Gibraan,Rahman ^[6] ; Morgan,Panitchpakdi ^[4] ; Michael J,Meehan ^[4] ; Kelly C,Weldon ^[5] ; Colette,Blach ^[7] ; Leyla,Schimmel ^[7] ; Rima,Kaddurah-Daouk ^[7] ; Pieter C,Dorrestein ^[5] ; Rob,Knight ^[8] ; Suzanne,Craft ^[9] ; Alzheimer's Gut Microbiome Project Consortium

作者单位： Department of Pediatrics, University of California San Diego, La Jolla, California, USA.;Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA. ^[1] Department of Pediatrics, University of California San Diego, La Jolla, California, USA.;Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, USA.;Center for Microbiome Innovation, Joan and Irwin Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA. ^[2] Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. ^[3] Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA.;Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA. ^[4] Center for Microbiome Innovation, Joan and Irwin Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.;Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA.;Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA. ^[5] Department of Pediatrics, University of California San Diego, La Jolla, California, USA.;Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, USA. ^[6] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.;Department of Medicine, Duke University, Durham, North Carolina, USA.;Duke Institute of Brain Sciences, Duke University, Durham, North Carolina, USA. ^[7] Department of Pediatrics, University of California San Diego, La Jolla, California, USA.;Center for Microbiome Innovation, Joan and Irwin Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.;Department of Bioengineering, University of California San Diego, La Jolla, California, USA.;Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA. ^[8] Department of Internal Medicine, Section on Geriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. ^[9]

关键词 Alzheimer's disease ketogenic diet low-fat American Heart Association Diet (AHAD)metabolome microbiome mild cognitive impairment

医学主题词美国(United States);人类(Humans);成年人(Adult);阿尔茨海默病(Alzheimer Disease);膳食, 限制脂肪(Diet, Fat-Restricted);代谢组(Metabolome);发作(Seizures);酮体类(Ketone Bodies);γ氨基丁酸(gamma-Aminobutyric Acid)

DOI 10.1002/alz.13007

PMID 37017243

发布时间 2025-05-29

基金项目

R01 AG046171/AG/NIA NIH HHS/United States U24 AG021886/AG/NIA NIH HHS/United States U19 AG063744/AG/NIA NIH HHS/United States RF1 AG059093/AG/NIA NIH HHS/United States NH/NIH HHS/United States U01 AG061359/AG/NIA NIH HHS/United States RF1 AG057452/AG/NIA NIH HHS/United States P30 AG072947/AG/NIA NIH HHS/United States RF1 AG051550/AG/NIA NIH HHS/United States RF1 AG0151550/AG/NIA NIH HHS/United States

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