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A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum.

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第一作者： Jansy P,Sarathy

第一单位： Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

作者： Jansy P,Sarathy ^[1] ; Min,Xie ^[1] ; Richard M,Jones ^[2] ; Adrienne,Chang ^[3] ; Paulina,Osiecki ^[1] ; Danielle,Weiner ^[4] ; Wen-Shan,Tsao ^[1] ; Maureen,Dougher ^[1] ; Landry,Blanc ^[5] ; Nader,Fotouhi ^[6] ; Laura E,Via ^[4] ; Clifton E,Barry ^[7] ; Iwijn,De Vlaminck ^[3] ; David R,Sherman ^[2] ; Véronique A,Dartois ^[8]

作者单位： Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA. ^[1] Department of Microbiology, University of Washington, Seattle, Washington, USA. ^[2] Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA. ^[3] Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.;Tuberculosis Imaging Program, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, USA. ^[4] University of Bordeaux, CNRS, CBMN, UMR 5248, Pessac, France. ^[5] Global Alliance for TB Drug Development, New York, New York, USA. ^[6] Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.;Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ^[7] Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.;Hackensack Meridian School of Medicine, Department of Medical Sciences, Nutley, New Jersey, USA. ^[8]

关键词 caseum nonreplicating Mycobacterium tuberculosis persister tuberculosis vulnerable target

主题词动物(Animals);结核分枝杆菌(Mycobacterium tuberculosis);抗结核药(Antitubercular Agents);结核(Tuberculosis);结核, 抗多种药物性(Tuberculosis, Multidrug-Resistant);脂类(Lipids)

DOI 10.1128/mbio.00598-23

PMID 37017524

发布时间 2023-05-09

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准确一般字义偏差语意偏离译文作用小提交