Antitumor activity and mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lung cancer with EGFR<sup>L858R/T790M</sup> mutation.

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作者： Lumei,Dai ^[1] ; Feng,Qin ^[2] ; Yuying,Xie ^[1] ; Bin,Zhang ^[3] ; Zhijie,Zhang ^[1] ; Sijia,Liang ^[1] ; Fujia,Chen ^[1] ; Xiaochao,Huang ^[4] ; Hengshan,Wang ^[5]

作者单位： School of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China. ^[1] State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China. ^[2] School of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China. Electronic address: zhbin308@163.com. ^[3] State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huaian 223003, China. Electronic address: viphuangxc@126.com. ^[4] State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China. Electronic address: whengshan@163.com. ^[5]

关键词 Anticancer DNA damage EGFR inhibitors Nitrogen mustard Quinazoline