Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses.

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第一作者： Qin,Zeng

第一单位： Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

作者： Qin,Zeng ^[1] ; Shuyi,Wang ^[2] ; Mengyuan,Li ^[1] ; Shuang,Wang ^[1] ; Chaohuan,Guo ^[1] ; Xinyuan,Ruan ^[1] ; Ryu,Watanabe ^[3] ; Yimei,Lai ^[1] ; Yuefang,Huang ^[4] ; Xiaoyu,Yin ^[5] ; Chuanzhao,Zhang ^[6] ; Binfeng,Chen ^[1] ; Niansheng,Yang ^[7] ; Hui,Zhang ^[8]

作者单位： Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. ^[1] Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: wangshy23@mail2.sysu.edu.cn. ^[2] Department of Clinical Immunology, Osaka Metropolitan University, Graduate School of Medicine, Osaka 5458585, Japan. ^[3] Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. ^[4] Department of Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. ^[5] Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. ^[6] Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: yangnsh@mail.sysu.edu.cn. ^[7] Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; Institue of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zhangh656@mail.sysu.edu.cn. ^[8]

关键词 CD36 acetylcholine autoreactive B cell responses choline acetyltransferase fibroblastic reticular cells lipid metabolism mitochondrial respiration spleen systemic lupus erythematosus

主题词小鼠(Mice);动物(Animals);脾(Spleen);乙酰胆碱(Acetylcholine);脂类代谢(Lipid Metabolism);红斑狼疮, 系统性(Lupus Erythematosus, Systemic);脂类(Lipids)

DOI 10.1016/j.cmet.2023.03.010

PMID 37019104

发布时间 2023-05-07

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