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The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors.

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第一作者： Giada,Del Baldo

第一单位： Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy Bambino Gesù Children's Hospital, Scientific Institute for Reasearch, Hospitalization and Healthcare (IRCCS), Rome, Italy.;Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

作者： Giada,Del Baldo ^[1] ; Francesca,Del Bufalo ^[2] ; Claudia,Pinacchio ^[2] ; Andrea,Carai ^[3] ; Concetta,Quintarelli ^[2] ; Biagio,De Angelis ^[2] ; Pietro,Merli ^[2] ; Antonella,Cacchione ^[2] ; Franco,Locatelli ^[4] ; Angela,Mastronuzzi ^[2]

作者单位： Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy Bambino Gesù Children's Hospital, Scientific Institute for Reasearch, Hospitalization and Healthcare (IRCCS), Rome, Italy.;Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. ^[1] Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy Bambino Gesù Children's Hospital, Scientific Institute for Reasearch, Hospitalization and Healthcare (IRCCS), Rome, Italy. ^[2] Department of Neurosciences, Neurosurgery Unit, Bambino Gesù Children's Hospital, Scientific Institute for Reasearch, Hospitalization and Healthcare (IRCCS), Rome, Italy. ^[3] Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy Bambino Gesù Children's Hospital, Scientific Institute for Reasearch, Hospitalization and Healthcare (IRCCS), Rome, Italy.;Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy. ^[4]

关键词 CAR-T cells blood-brain barrier glymphatic system neurotoxicity pediatric brain tumors

医学主题词人类(Humans);儿童(Child);免疫疗法, 过继(Immunotherapy, Adoptive);中枢神经系统肿瘤(Central Nervous System Neoplasms);脑肿瘤(Brain Neoplasms);T淋巴细胞(T-Lymphocytes);血脑屏障(Blood-Brain Barrier)

DOI 10.3389/fimmu.2023.1142597

PMID 37025994

发布时间 2023-04-17

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