Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway.

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第一作者： Yiying,Zhu

第一单位： Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Life Science, Yunnan University, Kunming, 650091, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

作者： Yiying,Zhu ^[1] ; Zhangxun,Zhao ^[2] ; Minggao,Xue ^[3] ; Dan,Wang ^[3] ; Guifeng,Su ^[1] ; Xiaoman,Ju ^[2] ; Qihong,Yang ^[2] ; Shaohua,Zhang ^[1] ; Dongmei,Fan ^[2] ; Huifang,Zhu ^[4] ; Min,Yu ^[3] ; Yan,Li ^[1] ; Lingmei,Kong ^[5] ; Hongyu,Zhou ^[6]

作者单位： Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Life Science, Yunnan University, Kunming, 650091, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. ^[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. ^[2] Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Life Science, Yunnan University, Kunming, 650091, China. ^[3] Neonatal/Pediatric Intensive Care Unit, Children's Medical Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. ^[4] Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Life Science, Yunnan University, Kunming, 650091, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. Electronic address: konglingmei@ynu.edu.cn. ^[5] School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, Yunnan, China. Electronic address: zhouhongyu@kmmu.edu.cn. ^[6]

关键词 Ciclopirox olamine Immunotherapy NKG2D ligands Natural killer cells

主题词人类(Humans);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);NK细胞凝集素样受体亚家族K(NK Cell Lectin-Like Receptor Subfamily K);杀伤细胞, 天然(Killer Cells, Natural);信号传导(Signal Transduction);白血病(Leukemia);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1016/j.bbrc.2023.03.062

PMID 37030020

发布时间 2023-04-26

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