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Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli.

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第一作者： Mikhail,Liskovykh

第一单位： Developmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. mikhail.liskovykh@nih.gov.

作者： Mikhail,Liskovykh ^[1] ; Nikolai S,Petrov ^[2] ; Vladimir N,Noskov ^[2] ; Hiroshi,Masumoto ^[3] ; William C,Earnshaw ^[4] ; David,Schlessinger ^[5] ; Svetlana A,Shabalina ^[6] ; Vladimir,Larionov ^[7] ; Natalay,Kouprina ^[8]

作者单位： Developmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. mikhail.liskovykh@nih.gov. ^[1] Developmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. ^[2] Laboratory of Chromosome Engineering, Department of Frontier Research and Development, Kazusa DNA Research Institute, Kisarazu, Chiba, 292-0818, Japan. ^[3] Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, Scotland, UK. ^[4] National Institute on Aging, Laboratory of Genetics and Genomics, NIH, Baltimore, MD, 21224, USA. ^[5] National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD, 20892, USA. ^[6] Developmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. larionov@mail.nih.gov. ^[7] Developmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. kouprinn@mail.nih.gov. ^[8]

关键词 Human artificial chromosome (HAC)Nucleolar organizer regions (NORs)Ribosomal DNA Transformation-associated recombination (TAR)rDNA

医学主题词人类(Humans);核仁组成区(Nucleolus Organizer Region);DNA, 核糖体(DNA, Ribosomal);细胞核仁(Cell Nucleolus);染色体, 人(Chromosomes, Human)

DOI 10.1007/s00018-023-04770-3

PMID 37043028

发布时间 2025-05-30

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