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首页> Journal of pharmaceutical and biomedical analysis> Development of an enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of methorphan and its O-demethylated metabolite in human blood and its application to post-mortem samples.

Development of an enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of methorphan and its O-demethylated metabolite in human blood and its application to post-mortem samples.

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作者： Alfredo Fabrizio,Lo Faro ^[1] ; Diletta,Berardinelli ^[1] ; Giorgia,Sprega ^[1] ; Anastasio,Tini ^[1] ; Jeremy,Carlier ^[1] ; Tivadar,Farkas ^[2] ; Francesco Paolo,Busardò ^[3] ; Bezhan,Chankvetadze ^[4]

作者单位： Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy. ^[1] Phenomenex Inc., 411 Madrid Ave., Torrance, 90501 CA, USA. ^[2] Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy. Electronic address: f.p.busardo@univpm.it. ^[3] Tbilisi State University, Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, 0179 Tbilisi, Georgia. ^[4]

关键词 Dextromethorphan Dextrorphan Enantioselective analysis Levomethorphan Levorphanol

主题词人类(Humans);右美沙芬(Dextromethorphan);色谱法, 高压液相(Chromatography, High Pressure Liquid);右啡烷(Dextrorphan);色谱法, 液相(Chromatography, Liquid);串联质谱法(Tandem Mass Spectrometry);立体异构现象(Stereoisomerism);左啡诺(Levorphanol)

DOI 10.1016/j.jpba.2023.115384

PMID 37044005

发布时间 2023-05-05

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Journal of pharmaceutical and biomedical analysis

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