Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis.

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第一作者： Ana Belen,Moreno-Castaño

第一单位： Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Biomedical Diagnostic Center (CDB), Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain abmoreno@clinic.cat.

作者： Ana Belen,Moreno-Castaño ^[1] ; Sara,Fernández ^[2] ; Helena,Ventosa ^[3] ; Marta,Palomo ^[3] ; Julia,Martinez-Sanchez ^[4] ; Alex,Ramos ^[5] ; Valentín,Ortiz-Maldonado ^[5] ; Julio,Delgado ^[6] ; Carlos,Fernández de Larrea ^[2] ; Alvaro,Urbano-Ispizua ^[6] ; Olaf,Penack ^[2] ; J M,Nicolás ^[6] ; Adrian,Téllez ^[2] ; Gines,Escolar ^[6] ; Enric,Carreras ^[7] ; Francesc,Fernández-Avilés ^[2] ; Pedro,Castro ^[3] ; Maribel,Diaz-Ricart ^[3]

作者单位： Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Biomedical Diagnostic Center (CDB), Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain abmoreno@clinic.cat. ^[1] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Spain. ^[2] Intensive Care Unit, Clinical Institute of Medicine and Dermatology (ICMID), Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. ^[3] Hematology External Quality Assessment Laboratory, Biomedical Diagnostic Center (CDB), Hospital Clínic de Barcelona, Barcelona, Spain. ^[4] Institut de Recerca Contra la Leucèmia Josep Carreras, Campus Clínic, Barcelona, Spain. ^[5] Hematology Department, Clinical Institute of Hematologic and Oncologic Diseases (ICMHO), Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. ^[6] Hematology Department, Charité Universitätsmedizin Berlin, Berlin, Germany. ^[7] Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Biomedical Diagnostic Center (CDB), Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. ^[8] Fundación Josep Carreras contra la Leucemia, Josep Carreras Leukaemia Research Institute, Barcelona, Spain. ^[9]

关键词 antineoplastic protocols cytotoxicity, immunologic hematologic neoplasms immunity, cellular immunotherapy

主题词人类(Humans);T淋巴细胞(T-Lymphocytes);止血药(Hemostatics);von Willebrand因子(von Willebrand Factor);诊断, 鉴别(Diagnosis, Differential);纤溶酶原激活物抑制物1(Plasminogen Activator Inhibitor 1);止血(Hemostasis);血液肿瘤(Hematologic Neoplasms);脓毒症(Sepsis)

DOI 10.1136/jitc-2022-006365

PMID 37045474

发布时间 2023-06-26

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Journal for immunotherapy of cancer

2023年11卷4期

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Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis.

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Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis.

Journal for immunotherapy of cancer

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