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DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies.

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第一作者： Shohei,Kikuchi

第一单位： Department of Hematology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

作者： Shohei,Kikuchi ^[1] ; Akinori,Wada ^[1] ; Yusuke,Kamihara ^[1] ; Kosuke,Okazaki ^[2] ; Paras,Jawaid ^[1] ; Mati Ur,Rehman ^[3] ; Eiji,Kobayashi ^[4] ; Takeshi,Susukida ^[5] ; Tomoki,Minemura ^[1] ; Yoshimi,Nabe ^[1] ; Noriaki,Iwao ^[6] ; Tatsuhiko,Ozawa ^[4] ; Ryo,Hatano ^[7] ; Mitsugu,Yamada ^[8] ; Hiroyuki,Kishi ^[4] ; Yuji,Matsuya ^[9] ; Mineyuki,Mizuguchi ^[9] ; Yoshihiro,Hayakawa ^[5] ; Nam H,Dang ^[10] ; Yasumitsu,Sakamoto ^[11] ; Chikao,Morimoto ^[7] ; Tsutomu,Sato ^[1]

作者单位： Department of Hematology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. ^[1] Center for Clinical Research, Toyama University Hospital, 2630 Sugitani, Toyama 930-0194, Japan. ^[2] Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi 74800, Pakistan. ^[3] Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. ^[4] Section of Host Defences, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. ^[5] Department of Hematology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni City, Shizuoka 410-2295, Japan. ^[6] Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421, Japan. ^[7] JEM Utilization Center Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), 2-1-1 Sengen, Tsukuba-shi 305-8505, Japan. ^[8] Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. ^[9] Division of Hematology/Oncology, University of Florida, Gainesville, FL 32610, USA. ^[10] School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba 028-3694, Japan. ^[11]

关键词 DPP8 anticancer agent hematological inhibitor malignancies

医学主题词血液肿瘤(Hematologic Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);抗肿瘤药(Antineoplastic Agents);人类(Humans);蛋白酶抑制药(Protease Inhibitors)

DOI 10.3390/cells12071100

PMID 37048172

发布时间 2025-08-01

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