Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors.

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作者： Shaima,Hasan ^[1] ; Kawthar,Kayed ^[1] ; Rose,Ghemrawi ^[2] ; Nezar Al,Bataineh ^[1] ; Radwa E,Mahgoub ^[2] ; Rola,Audeh ^[1] ; Raghad,Aldulaymi ^[2] ; Noor,Atatreh ^[2] ; Mohammad A,Ghattas ^[1]

作者单位： College of Pharmacy, Al Ain University, Abu Dhabi 64141, United Arab Emirates. ^[1] AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi 64141, United Arab Emirates. ^[2]

关键词 FabI antimicrobial activity diphenyl methane docking enoyl-acyl carrier protein transferase lead optimization molecular dynamic simulation triclosan

主题词抗菌药(Anti-Bacterial Agents);烯酰-(酰基载体蛋白)还原酶(NADH)(Enoyl-(Acyl-Carrier-Protein) Reductase (NADH));革兰氏阴性菌(Gram-Negative Bacteria);酶抑制剂(Enzyme Inhibitors);革兰氏阳性菌(Gram-Positive Bacteria);细菌(Bacteria);分子动力学模拟(Molecular Dynamics Simulation)

DOI 10.3390/molecules28073000

PMID 37049763

发布时间 2023-04-15

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准确一般字义偏差语意偏离译文作用小提交