RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.

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作者： Markus,Blatter ^[1] ; Charlotte,Meylan ^[1] ; Antoine,Cléry ^[1] ; Roberto,Giambruno ^[2] ; Yaroslav,Nikolaev ^[1] ; Michel,Heidecker ^[1] ; Jessica Arvindbhai,Solanki ^[3] ; Manuel O,Diaz ^[3] ; Davide,Gabellini ^[2] ; Frédéric H-T,Allain ^[1]

作者单位： Department of Biology, Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland. ^[1] Gene Expression and Muscular Dystrophy Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. ^[2] Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago Medical Center, University of Chicago, Chicago, IL, USA. ^[3]

主题词人类(Humans);组蛋白类(Histones);髓淋巴细胞性白血病蛋白质(Myeloid-Lymphoid Leukemia Protein);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);DNA结合蛋白质类(DNA-Binding Proteins);RNA(RNA);白血病(Leukemia)

DOI 10.1126/sciadv.adf5330

PMID 37075125

发布时间 2023-04-22

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Science advances

2023年9卷16期

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RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.

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RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.

Science advances

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