A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer.

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作者： Jinghui,Liu ^[1] ; Yue,Zhao ^[2] ; Daheng,He ^[3] ; Katelyn M,Jones ^[1] ; Shan,Tang ^[2] ; Derek B,Allison ^[4] ; Yanquan,Zhang ^[1] ; Jing,Chen ^[5] ; Qiongsi,Zhang ^[1] ; Xinyi,Wang ^[1] ; Chaohao,Li ^[1] ; Chi,Wang ^[3] ; Lang,Li ^[2] ; Xiaoqi,Liu ^[6]

作者单位： Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA. ^[1] Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA. ^[2] Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. ^[3] Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA. ^[4] Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA. ^[5] Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address: xiaoqi.liu@uky.edu. ^[6]

关键词 ATM CK1α CRISPR screening enzalutamide prostate cancer

主题词男(雄)性(Male);人类(Humans);酪蛋白激酶Ⅰα(Casein Kinase Ialpha);苯硫乙内酰脲(Phenylthiohydantoin);DNA(DNA)

DOI 10.1016/j.xcrm.2023.101015

PMID 37075701

发布时间 2024-05-27

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Cell reports. Medicine

2023年4卷4期

101015页

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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer.

Cell reports. Medicine

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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer.

Cell reports. Medicine

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Cell reports. Medicine

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