CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the <i>Gnao1</i> for safety studies of RNA therapeutics.

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第一作者： Anna V,Polikarpova

第一单位： Laboratory of Modeling and Gene Therapy of Hereditary Diseases, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.

作者： Anna V,Polikarpova ^[1] ; Tatiana V,Egorova ^[2] ; Evgenii A,Lunev ^[1] ; Alexandra A,Tsitrina ^[2] ; Svetlana G,Vassilieva ^[1] ; Irina M,Savchenko ^[2] ; Yuliya Y,Silaeva ^[3] ; Alexey V,Deykin ^[4] ; Maryana V,Bardina ^[1]

作者单位： Laboratory of Modeling and Gene Therapy of Hereditary Diseases, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia. ^[1] Marlin Biotech, Sochi, Russia. ^[2] Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. ^[3] Koltzov Institute of Developmental Biology Russian Academy of Sciences, Moscow, Russia. ^[4] Core Facility Center, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia. ^[5] Laboratory of Genetic Technologies and Genome Editing for Biomedicine and Animal Health, Joint Center for Genetic Technologies, Belgorod National Research University, Belgorod, Russia. ^[6]

关键词 CRISPR/Cas9 GNAO1 encephalopathy genetically modified mice genome editing personalized medicine

DOI 10.3389/fgeed.2023.1034720

PMID 37077890

发布时间 2023-04-21

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Frontiers in genome editing

2023年5卷

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CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the <i>Gnao1</i> for safety studies of RNA therapeutics.

Frontiers in genome editing

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Frontiers in genome editing

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CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the <i>Gnao1</i> for safety studies of RNA therapeutics.

Frontiers in genome editing

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Frontiers in genome editing

相关期刊

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